Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila
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چکیده
منابع مشابه
Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila.
Chromatin insulators or boundaries are proposed to structure the chromatin fiber into functionally independent domains by promoting the formation of chromatin loops. These elements can block the communication between an enhancer and a gene when placed between them. Interestingly, it has been previously observed that two tandem copies of the Drosophila Su(Hw) insulator abolish this enhancer-bloc...
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15 صفحه اولIsolation of cDNAs encoding the Drosophila GAGA transcription factor.
To investigate the mechanisms involved in expression of the Drosophila melanogaster engrailed gene, we purified GAGA protein, one of several putative transcriptional activator proteins that binds to the proximal region of the engrailed promoter. Antibodies raised against GAGA protein were used to demonstrate that the protein is present in all nuclei of young embryos. We isolated cDNA clones enc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0403959101